Functional and molecular identification of intermediate-conductance Ca -activated K channels in breast cancer cells: association with cell cycle progression
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چکیده
Halima Ouadid-Ahidouch, Morad Roudbaraki, Philippe Delcourt, Ahmed Ahidouch, Nathalie Joury, and Natalia Prevarskaya Laboratoire de Physiologie Cellulaire, Institut National de la Santé et de la Recherche Médicale EMI 0228, SN3, Université des Sciences et Technologies de Lille, 59655 Villeneuve d’Ascq Cédex; Laboratoire de Physiologie Cellulaire et Moléculaire, Université Picardie Jules Verne, Faculté des Sciences, 80000 Amiens; Institut Fédératif de Recherche IFR22: “Biologie et Pathologie des Régulations Cellulaires,” IRCL, 59045 Lille Cédex, France; and Laboratoire de Physiologie Animale, Université Ibnou Zohr, Faculté des Sciences, Agadir, Morocco BP2815 80000
منابع مشابه
Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression.
We have previously reported that the hEAG K(+) channels are responsible for the potential membrane hyperpolarization that induces human breast cancer cell progression into the G1 phase of the cell cycle. In the present study, we evaluate the role and functional expression of the intermediate-conductance Ca(2+)-activated K(+) channel, hIK1-like, in controlling cell cycle progression. Our results...
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Potassium channels have been involved in epithelial tumorigenesis but the role of small-conductance Ca(2+)-activated K(+) channels is unknown. We report here that small-conductance Ca(2+)-activated K(+) channels are expressed in a highly metastasizing mammary cancer cell line, MDA-MB-435s. Patch-clamp recordings showed typical small-conductance Ca(2+)-activated K(+) channel-mediated currents se...
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Ion channels are important in controlling cell cycle progression and proliferation in a variety of cell types. Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II d...
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Dutta AK, Khimji A, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP. Identification and functional characterization of the intermediate-conductance Ca -activated K channel (IK-1) in biliary epithelium. Am J Physiol Gastrointest Liver Physiol 297: G1009–G1018, 2009. First published September 17, 2009; doi:10.1152/ajpgi.00223.2009.—In the liver, adenosine triphosphate (ATP) is ...
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Bone marrow mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine; however, their cellular physiology is not fully understood. The present study aimed at exploring the potential roles of the two dominant functional ion channels, intermediate-conductance Ca(2+)-activated potassium (IK(Ca)) and volume-sensitive chloride (I(Cl.vol)) channels, in regulating proliferati...
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تاریخ انتشار 2004